Chlamydia trachomatis in human immunodeficiency virus-infected men treated at a referral hospital for sexually transmitted diseases in the Amazonas, Brazil

OBJECTIVES: The aim of the present study was to determine the Chlamydia trachomatis prevalence and to identify the demographic, behavioural and clinical factors associated with C. trachomatis in human immunodeficiency virus infected men. STUDY: This was a cross-sectional study of C. trachomatis prevalence among human immunodeficiency virus-infected men enrolled at the Outpatient clinic of acquired immunodeficiency syndrome of the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado in Manaus, Amazonas, Brazil. C. trachomatis deoxyribonucleic acid from urethral samples was purified and submitted to real time polymerase chain reaction to identify the presence of C. trachomatis. RESULTS: A total of 276 human immunodeficiency virus-infected men were included in the study. The prevalence of C. trachomatis infection was 12% (95% confidence interval 8.1%-15.7%). The mean age of the participants was 34.63 (standard deviation 10.80) years. Of the 276 human immunodeficiency virus-infected men, 93 (56.2%) had more than one sexual partner in the past year and 105 (38.0%) reported having their first sexual intercourse under the age of 15 years. Men having sex with men and bisexuals amounted to 61.2% of the studied population. A total of 71.7% had received human immunodeficiency virus diagnosis in the last three years and 55.1% were using antiretroviral therapy. Factors associated with C. trachomatis infection in the logistic model were being single (p<0.034), men having sex with men (p<0.021), and having previous sexually transmitted diseases (p<0.001). CONCLUSION: The high prevalence of C. trachomatis infection among human immunodeficiency virus-infected men highlights that screening human immunodeficiency virus-infected men for C. trachomatis, especially among men having sex with men, is paramount to control the spread of C. trachomatis infection. .

Obesity and dyslipidemia in patients with psoriasis treated at a dermatologic clinic in Manaus / Obesidade e dislipidemia em pacientes com psoriase atendidos num ambulatorio de dermatologia de Manaus

BACKGROUND: Psoriasis is a chronic inflammatory disease of multifactorial etiology, with participation of genetic, autoimmune and environmental factors. Recent studies have demonstrated the role of inflammatory cells and mediators in the pathogenesis of psoriasis, which is now defined as a systemic and autoimmune inflammatory disease that may be associated with other diseases of inflammatory nature. OBJECTIVES: To evaluate the occurrence of obesity and dyslipidemia in patients with psoriasis treated at a dermatology clinic in Manaus. METHODS: We performed a prospective descriptive study to assess the prevalence of obesity and dyslipidemia in patients with psoriasis. Besides the recommended dermatological care, a physical examination was performed to measure weight, height and waist circumference. RESULTS: We included 72 patients, 44 (61.1%) female and 28 (38.9%) male, with a mean age of 51.0 years ± 15.9 years. As for body mass index (BMI), 16 (22.2%) were overweight and 20 (27.8%) were obese. In the analysis of waist circumference in relation to gender, we found that 79.5% of women surveyed had central obesity, a percentage statistically higher than that observed among men (42.9%) at the 5% level of significance (p = 0.001). Regarding the diagnosis of dyslipidemia, 29 (65.9%) females and 22 (78.6%) males showed alterations in lipid profile. CONCLUSIONS: The occurrence of dyslipidemia and obesity in patients with psoriasis can affect life quality and expectancy, increasing the risk of systemic and metabolic diseases, which makes periodic investigation of these comorbidities in patients with psoriasis mandatory. .

FUNDAMENTOS: A psoríase é uma doença inflamatória crônica, com etiologia multifatorial, com participação de fatores genéticos, auto-imunes e ambientais. Estudos recentes demonstram o papel de células e mediadores inflamatórios na patogênese da psoríase, que passou a ser definida como uma afecção inflamatória sistêmica e auto-imune, podendo associarse a outras doenças de natureza inflamatória. OBJETIVOS: Avaliar a ocorrência de obesidade e dislipidemia em pacientes com psoríase atendidos num ambulatório de dermatologia de Manaus. MÉTODOS: Foi realizado estudo descritivo e prospectivo para avaliar a ocorrência de obesidade e dislipidemia em pacientes com psoríase. Além do atendimento dermatológico preconizado, foi realizado exame físico com medida de peso, altura e circunferência abdominal. RESULTADOS: Foram incluídos 72 pacientes, sendo 44 (61,1%) do sexo feminino e 28 (38,9%) do sexo masculino, com média de idade de 51,0 anos ± 15,9 anos. Quanto ao índice de massa corporal, 16 (22,2%) apresentavam sobrepeso e 20 (27,8%), obesidade. Na análise da circunferência abdominal em relação ao gênero, observou-se que 79,5% das mulheres examinadas apresentavam obesidade central, percentual estatisticamente maior que o observado entre os homens (42,9%), ao nível de 5% de significância (p= 0,001). Em relação ao diagnóstico de dislipidemia, 29 (65,9%) do sexo feminino e 22 (78,6%) do masculino apresentaram alteração no lipidograma. CONCLUSÕES: A ocorrência de dislipidemia e obesidade nos pacientes com psoríase pode alterar a qualidade e expectativa de vida, aumentando o risco de doenças sistêmicas e metabólicas, o que torna obrigatória a investigação periódica dessas ...